EC Number   |
General Information |
Reference |
|---|
    2.4.2.28 | malfunction |
enzyme knockdown both genetically and pharmacologically, blocks androgen sensitive prostate cancer growth in vivo |
736923 |
| 2.4.2.28 | malfunction |
mice homozygous for a MTAP null allele (MtaplacZ) have an embryonic lethal phenotype dying around day 8 postconception. Mtap/MtaplacZ heterozygotes are born at Mendelian frequencies and appear indistinguishable from wild-type mice during the first year of life, but tend to die prematurely with a median survival of 585 days. These animals have greatly enlarged spleens, altered thymic histology, and lymphocytic infiltration of their livers, consistent with lymphoma |
703023 |
| 2.4.2.28 | malfunction |
none of MTAN deletion mutants interact with calcineurin B-like 3 |
700813 |
| 2.4.2.28 | malfunction |
there is increased deoxyadenosine sensitivity in Trypanosoma brucei methylthioadenosine phosphorylase knockdown cells |
-, 736501 |
| 2.4.2.28 | metabolism |
the enzyme is part of the purine pathway salvage |
760012 |
| 2.4.2.28 | physiological function |
MTAN is involved in pollen development |
700813 |
| 2.4.2.28 | physiological function |
Mtap is essential during embryogenesis. Mtap is a tumor suppressor gene independent of CDKN2A and ARF |
703023 |
| 2.4.2.28 | physiological function |
MTAP substrates protect MTAP-positive cells from toxicity of adenine analogs 2,6-diaminopurine, 6-methylpurine, and 2-fluoroadenine and clinical cancer drugs 5-fluorouracil or 6-thioguanine. Adenine analog plus 5'-methylthioadenosine, kills MTAP-negative A549 lung tumor cells, while MTAP-positive human fibroblasts are protected, whereas in co-cultures of the breast tumor cell line, MCF-7, and HF cells, MCF-7 is inhibited or killed, while HF cells proliferate robustly |
706428 |
| 2.4.2.28 | physiological function |
role of MTAN in quorum sensing |
700355 |
| 2.4.2.28 | physiological function |
the enzyme is associated with coronary artery disease risk in a Chinese Han population |
736173 |
