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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.244malfunction B4GALNT3 overexpression enhances colon cancer cell malignant phenotypes in vitro and in vivo. B4GALNT3 knockdown suppresses EGF-induced phosphorylation of epithelial growth factor receptor, EGFR, and its downstream signaling molecules. B4GALNT3 knockdown inhibits EGFR activity, decreases EGF-induced migration and invasion in colon cancer cells, and promotes EGFR degradation in colon cancer cells, overview 736917
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.244physiological function beta1,4-N-acetylgalactosaminyltransferase III modulates cancer stemness through EGFR signaling pathway in colon cancer cells, B4GALNT3 regulates cancer stemness and the invasive properties of colon cancer cells through modifying EGFR glycosylation and signaling. B4GALNT3 expression is positively correlated with advanced stages and poor survival in colorectal cancer patients 736917
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