EC Number   |
General Information |
Reference |
|---|
    2.3.3.8 | evolution |
structural studies unmask a fundamental evolutionary relationship that links citrate synthase, the first enzyme of the oxidative Krebs cycle, to an ancestral tetrameric citryl-CoA lyase module that operates in the reverse Krebs cycle. This molecular transition marked a key step in the evolution of metabolism on Earth |
757804 |
| 2.3.3.8 | malfunction |
ATP citrate lyase knockdown induces proliferation arrest, cell-cycle arrest, and apoptosis in cancer cells and results in elevated expression of acyl-CoA synthetase short-chain family member 2 |
720439 |
| 2.3.3.8 | malfunction |
ATP citrate lyase silencing impairs myoblast and satellite cell differentiation, and it is accompanied by a decrease in fast myosin heavy chain isoforms and MYOD |
756395 |
| 2.3.3.8 | malfunction |
decrease in ATP level, energy charge, and fatty acid content in mutant edt1 anthers |
758054 |
| 2.3.3.8 | malfunction |
deletion of the enzyme results in a complete loss of self and female fertility as well as a reduction in asexual reproduction, virulence, and trichothecene production. Although lipid synthesis is not affected by enzyme deletion, histone acetylation is dramatically reduced in the enzyme deletion mutants during sexual development |
-, 719545 |
| 2.3.3.8 | malfunction |
enzyme activity inhibition as well as gene silencing lead to reduced nitric oxide, reactive oxygen species and prostaglandin E2 inflammatory mediators |
735597 |
| 2.3.3.8 | malfunction |
enzyme inactivation decreases fatty acid synthesis by 60 to 80% |
735713 |
| 2.3.3.8 | malfunction |
enzyme knockdown triggers cellular senescence and activation of tumor suppressor p53 |
736093 |
| 2.3.3.8 | malfunction |
inhibition of the enzyme suppresses in vitro glioblastoma cell migration, clonogenicity and brain invasion under glycolytic conditions and enhances the suppressive effects of a Met inhibitor on cell migration |
704077 |
| 2.3.3.8 | malfunction |
loss of ATP-citrate lyase results in severe developmental effects, with the production of asexual spores (conidia) being greatly reduced and a complete absence of sexual development |
-, 719383 |
