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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 2.3.1.B27physiological function the DNA binding affinity of the chromatin protein Alba1 is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA -, 725365
Display the reaction diagram Show all sequences 2.3.1.B27physiological function the Sulfolobus solfataricus protein acetyltransferase acetylates ALBA, an abundant nonspecific DNA-binding protein, on Lys16 to reduce its DNA affinity, and the Sir2 deacetylase reverses the modification to cause transcriptional repression. This represents a primitive model for chromatin regulation analogous to histone modification in eukaryotes -, 725388
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