EC Number   |
General Information |
Reference |
|---|
   2.3.1.85 | malfunction |
Fas2 KO strains are unable to form normal biofilms and are more efficiently killed by murine-like macrophages, J774.16, than the wild type, heterozygous and reconstituted strains, Fas2 KO strains are hypersensitive to human serum, and inhibition of Fas2 in wild type Candida parapsilosis by cerulenin significantly decreases fungal growth in human serum |
706450 |
| 2.3.1.85 | metabolism |
FASII supplies the C8 substrate for lipoic acid synthesis |
706445 |
| 2.3.1.85 | physiological function |
FASN produces phospholipids for membrane microdomains that accommodate receptor tyrosine kinases including epidermal growth factor-receptor ErbB1 and ErbB2 |
702058 |
| 2.3.1.85 | physiological function |
fatty acid synthase is a key enzyme regulating de novo fatty acid synthesis |
704214 |
| 2.3.1.85 | physiological function |
mice with fatty acid synthase knockout in the myocardium, FASKard, develop normally, manifest normal resting heart function, and have normal cardiac PPARalpha signaling as well as fatty acid oxidation. Mutant mice decompensate with stress. Most die within 1 h of transverse aortic constriction, probably due to arrhythmia. Voltage clamp measurements of FASKard cardiomyocytes show hyperactivation of L-type calcium channel current that can not be reversed with palmitate supplementation.Ca2+/calmodulin-dependent protein kinase II but not protein kinase A signaling is activated in FASKard hearts, and knockdown of fatty acid synthase in cultured cells activates Ca2+/calmodulin-dependent protein kinase II. In addition to being intolerant of the stress of acute pressure, FASKard hearts are also intolerant of the stress of aging, reflected as persistent CaMKII hyperactivation, progression to dilatation, and premature death by 1 year of age. Ca2+/calmodulin-dependent protein kinase II signaling appears to be pathogenic in FASKard hearts |
719958 |
| 2.3.1.85 | physiological function |
the Fas2 gene is essential for fungal growth in fatty acid-free medium, but dispensable in medium with fatty acids |
706450 |
