EC Number |
General Information |
Reference |
---|
2.3.1.225 | evolution |
homology and phylogeny of DHHC proteins, overview |
720174 |
2.3.1.225 | evolution |
the enzyme is an Asp-His-His-Cys motif (DHHC) palmitoyl transferase family member |
720097 |
2.3.1.225 | evolution |
the enzymes belong to the DHHC family, homology and phylogeny of DHHC proteins, overview |
720174 |
2.3.1.225 | evolution |
the PAT enzymes of Arabidopsis thaliana belong to the DHHC-CRD-containing PAT family, PAT enzymes share a common structure mainly composed of four predicted transmembrane domains and a stretch of Asp-His-His-Cys, DHHC, within a Cys-rich domain |
720754 |
2.3.1.225 | evolution |
TIP1 is a plant member of an evolutionarily conserved group of proteins that contains six ankyrin repeats and a DHHC-CRD and that are predicted to be integral membrane proteins |
720672 |
2.3.1.225 | malfunction |
apex-associated re-positioning of nucleus during root hair elongation was impaired by PAT4 loss-of-function |
758079 |
2.3.1.225 | malfunction |
apt1 null cells exhibit almost no acylprotein thioesterase activity toward palmitoyl-Gialpha1 |
718835 |
2.3.1.225 | malfunction |
depletion of cellular cholesterol with the drug methyl-beta-cyclodextrin results in inhibition of palmitoyltransferase activity and a redistribution of the remaining activity to membranes of higher density, the process is reversible by cholesterol addition |
719807 |
2.3.1.225 | malfunction |
expression of DHHC15 mutant C159S reduced PSD-95 synaptic clustering as well as the clustering of cell-surface AMPA receptor GluR2 subunits, which is dependent upon PSD-95 palmitoylation |
720174 |
2.3.1.225 | malfunction |
human HIP14 complements the temperature-sensitive growth phenotype rescuing the defect in receptor endocytosis that results from deleting AKR1. Expression of human DHHC9 in yeast fails to complement an erf2DELTA strain. Deletion of the SWF1 gene abolishes the palmitoylation of Snc1, Syn8, and Tlg1 in vivo. Vac8 palmitoylation is significantly reduced but not absent in cells lacking Pfa3. Deletion of the ERF2 gene results in a decrease in Ras2 palmitoylation and a reduced presence on the plasma membrane. The erf2 erf4 double mutant is no more severe than either of the single mutants, and overexpression of ERF2 suppresses some but not all alleles of erf4 |
720174 |