    2.3.1.167 | metabolism |
the relationship between taxane patterns and the expression of genes encoding the enzymes taxadiene synthase, 10-deacetylbaccatin III-10beta-O-acetyltransferase, baccatin III 13-O-(3-amino-3-phenylpropanoyl) transferase and 3'-N-debenzoyl-2'-deoxytaxol-N-benzoyltransferase, involved in early and late steps of the taxane pathway, overview. The most abundant taxane in the aerial parts is 10-deacetylbaccatin III, which increases as the plantlets grow, indicating a low conversion to baccatin III and taxol. In contrast, the levels of 10-deacetylbaccatin III in the roots remain lower than those of taxol. But in the aerial parts the expression of DBAT, which codes for the enzyme that converts 10-deacetylbaccatin III into baccatin III, does not increase with the age of plantlets, unlike that of the other three enzymes, suggesting that this gene controls a rate-limiting step in the taxane biosynthetic pathway |
720764 |
