EC Number   |
General Information |
Reference |
|---|
    2.1.4.1 | evolution |
CyrA is phylogenetically distinct from other amidinotransferases |
-, 719453 |
| 2.1.4.1 | malfunction |
AGAT deficiency (and consequently homoarginine and creatine deficiency) is associated with larger infarct volumes and worse neurological deficits compared with wild-type littermates. Homoarginine is absent in enzyme knockout AGAT-/- mice and increased in guanidinoacetate N-methyltransferase knockout mice, GAMT-/-. Cerebral damage and neurological deficits in experimental stroke are increased in AGAT-/- mice and attenuated by homoarginine supplementation, whereas infarct size in GAMT-/- mice is decreased compared with controls |
-, 735972 |
| 2.1.4.1 | malfunction |
enzyme-deficient mice develop cardiac dysfunction. Enzyme-deficient mice have rescuable changes in body water and organ weights suggesting a role for creatine as a compatible osmolyte. Creatine-naive enzyme-deficient mice have haemodynamic impairment with low left ventricular systolic pressure and reduced inotropy, lusitropy, and contractile reserve |
756356 |
| 2.1.4.1 | metabolism |
CyrA is involved in the pathway for biosynthesis of the polyketide-derived hepatotoxin cylindrospermopsin |
-, 719453 |
| 2.1.4.1 | metabolism |
plasma homoarginine as strongly associated with single nucleotide polymorphisms in the L-arginine:glycine amidinotransferase (AGAT) gene, and increased AGAT expression in a cell model is associated with increased homoarginine, link between plasma homoarginine and outcome after experimental ischemic stroke. Allele-specific homoarginine plasma levels across the L-arginine:glycine amidinotransferase (AGAT) genotypes, overview |
-, 735972 |
| 2.1.4.1 | more |
Biallelic expression of the L-arginine:glycine amidinotransferase gene with different methylation status between male and female primordial germ cells in chickens |
-, 737153 |
| 2.1.4.1 | more |
ligand-induced conformational changes in wild-type CyrA, structure-function-stability relationship, overview |
-, 719473 |
| 2.1.4.1 | physiological function |
creatine synthesis |
703632 |
