EC Number   |
General Information |
Reference |
|---|
    2.1.2.2 | malfunction |
depletion of the enzyme by small interfering RNA inhibits cell proliferation and blocks S-phase and mitotic entry in cultured Hep-G2 and BEL-7404 cells. Enzyme depletion decreases the proliferating cell nuclear antigen concentration |
736225 |
| 2.1.2.2 | malfunction |
transfecting cells with GART-siRNA suppresses proliferation and enhances temozolomide-induced apoptosis in glioma cells |
736945 |
| 2.1.2.2 | metabolism |
glycinamide ribonucleotide transformylase is a folate-dependent enzyme in the de novo purine pathway |
736225 |
| 2.1.2.2 | more |
the enzyme comprises residues 808-1010 for the hGAR Tfase domain (purN) from the native human trifunctional enzyme (purD-purM-purN) |
735672 |
| 2.1.2.2 | physiological function |
glycinamide ribonucleotide formyl transferase is frequently overexpressed in glioma and critically regulates the proliferation of glioma cells |
736945 |
| 2.1.2.2 | physiological function |
increased expression of glycinamide ribonucleotide transformylase promotes liver cancer cell proliferation, enzyme expression and functional significance in hepatocellular carcinoma cells from several patients, overview |
736225 |
