EC Number   |
General Information |
Reference |
|---|
    2.1.1.280 | malfunction |
overexpression of BjSMT in tobacco substantially enhances tolerance to selenite stress manifested as significantly higher fresh weight, plant height, and chlorophyll content than control plants. The BjSMT-transformed tobacco plants accumulate a high level of Se upon selenite stress, and the plants also have significantly increased MeSeCys production potential in their leaves. The enzyme is highly induced by selenite and especially selenate. BjSMT overexpressing plants maintain a higher level of GSH-Px activity and chlorophyll content under severe selenite treatment |
757333 |
| 2.1.1.280 | malfunction |
overexpression of SMT decreases the negative effect of selenium on sulforaphane synthesis, while knockdown of SMT by RNAi enhances the negative effect |
-, 737012 |
| 2.1.1.280 | metabolism |
an increase of SMT gene expression leads to a rise in APX and POX, but a suppression of CAT and GR enzymes activities in Astragalus chrysochlorus. Selenium might be involved in the antioxidant metabolism in Astragalus chrysochlorus |
755714 |
| 2.1.1.280 | metabolism |
detoxification of selenium-containing compounds |
692948 |
| 2.1.1.280 | metabolism |
enzyme plays a crucial role in the detoxification of selenium in Astragalus bisulcatus |
692151 |
| 2.1.1.280 | metabolism |
SMT is the key enzyme for Se-methylselenocysteine synthesis |
723454 |
| 2.1.1.280 | more |
the post-secondary structure assembled by conserved Cys207, Cys272, and Cys273 residues is believed to form such a geometrical catalytic pocket which will position the sulfur group of L-homocysteine in close proximity to Thr147, responsible for methyl group transfer by donating a hydrogen bond |
757333 |
| 2.1.1.280 | physiological function |
compared to wild type, ATP sulfurylase and selenocysteine methyltransferase, expressing plants also accumulate increased concentrations of selenium when treated with selenite. Selenocysteine methyltransferase, is able to carry out Se phytoremediation more efficiently when the plants are supplied with selenium in the form of selenate |
724863 |
| 2.1.1.280 | physiological function |
expression of BoSMT significantly enhances Se tolerance, high levels of Se accumulate in Broccoli plants exposed to selenate, but addition of high levels of 1 or 10 mM sulfate shows a strong inhibitory effect on Se accumulation |
723454 |
| 2.1.1.280 | physiological function |
plants can easily absorb and assimilate Se in the form of selenate and selenite through sulfur transport proteins and metabolic pathways and remove it by converting it into volatilized methylated forms. The Se substitution of S in proteins can destroy the molecular function of these proteins, so an increased level of Se is toxic to most organisms. In plants,selenates are reduced and assimilated to organic Se which can be converted to methylselenocysteine (MeSeCys) in addition to selenocysteine (SeCys), selenomethionine (SeMet), and dimethylselenide (DMSe). Selenocysteine methyltransferase (SMT) is the key enzyme responsible for Se-methylselenocysteine (MeSeCys) formation. Brassica juncea is a selenium accumulator. BjSMT also possesses a conserved Thr187 which is involved in transferring a methyl group to L-homocysteine (HoCys) by donating a hydrogen bond, suggesting that BjSMT can methylate both HoCys and SeCys substrates |
757333 |
