EC Number   |
General Information |
Reference |
|---|
   2.1.1.231 | evolution |
GerMIII is present on the biosynthetic gene cluster of dihydrochalcomycin, a macrolide antibiotic that is produced by the Streptomyces sp. KCTC 0041BP. Based on its dependency on the metallic cofactor requirement for its reaction, the enzyme resembles the Class-II plant OMTs |
756617 |
| 2.1.1.231 | metabolism |
the enzyme catalyzes the last step in the biosynthesis of the bioactive flavonoid ponciretin, biosynthetic pathways starting with glucose, overview |
735537 |
| 2.1.1.231 | more |
a double bond between the C2 and the C3 and a single-ring-appended conjugate-hydroxyl group are crucial for the favorable enzymatic conversions of the GerMIII catalysis, modeling and molecular docking |
756617 |
| 2.1.1.231 | physiological function |
the methylation at the 4'-hydroxyl group of the B-ring of flavonoids confers a structural constraint for autooxidation, importance of the regiospecific 4'-OMT |
756617 |
