EC Number   |
General Information |
Reference |
|---|
  2.1.1.194 | evolution |
bioinformatics analysis of the Cfr/RlmN family establishes their significant evolutionary link with radical-S-adenosyl-L-methionine enzymes. The RlmN subfamily is likely the ancestral form, whereas the Cfr subfamily arose via duplication and horizontal gene transfer |
705983 |
| 2.1.1.194 | physiological function |
Cfr confers a phenotype with resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A antibiotics. The RlmN knock out strain JW2501-1 is less sensitive to the antibiotics than standard laboratory strain HB101 |
706726 |
| 2.1.1.194 | physiological function |
cfr confers combined resistance to chloramphenicol, florfenicol and clindamycin |
705766 |
| 2.1.1.194 | physiological function |
the Cfr rRNA methyltransferase confers resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A antibiotics |
701724 |
