EC Number   |
General Information |
Reference |
|---|
   2.1.1.171 | evolution |
structural similarities with other methyltransferases are limited to the core S-adenosyl-L-methionine domain but not the target recognition domain |
719931 |
| 2.1.1.171 | malfunction |
disruption of the yhhF gene by kanamycin resistance marker leads to a loss of modification at guanine966. Doubling of strain JW3430 carrying the inactive rsmD gene is essentially the same as that of the parental Escherichia coli strain BW25141 |
674888 |
| 2.1.1.171 | malfunction |
enzyme deficiency increases initiation of translation from codons AUA, CAC and CAU (2 to 3.6fold) |
734794 |
| 2.1.1.171 | malfunction |
enzyme deletion has a subtle effect on maintenance of the reading frame |
-, 734085 |
| 2.1.1.171 | malfunction |
truncated constructs of Rv2966c lacking the N-terminal 18- or 23-amino acid residues and the mutant protein 3RM do not show any significant binding to either DNA or RNA nor any m2G966 methyltransferase activity |
719931 |
| 2.1.1.171 | more |
RsmD is unusual in its ability to withstand multiple amino acid substitutions of the active site. Such efficiency of RsmD may be useful to complete the modification of a 30S subunit ahead of the 30S subunit's involvement in translation |
721033 |
| 2.1.1.171 | more |
the N-terminal hairpin is a minimalist functional domain that helps Rv2966c in target recognition |
719931 |
