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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.5.5.3malfunction enzyme knockdown alters glycolate and oxalate levels 741999
Display the word mapDisplay the reaction diagram Show all sequences 1.5.5.3physiological function creation of a ProDH2 knock out mouse model. The lack of hydroxyproline dehydrogenase in primary hyperoxalurias mouse models results in lower levels of urinary oxalate excretion. In the double knockout mouse, lacking both glyoxylate reductase/hydroxypyruvate reductase Grhpr and ProDH2, calcium-oxalate crystal deposition in the kidney is prevented, when placed on a 1% hydroxyproline diet 764206
Display the word mapDisplay the reaction diagram Show all sequences 1.5.5.3physiological function the enzyme plays a role in growth regulation, reactive oxygen species generation, and activation of the apoptotic cascade 742832
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