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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.B5evolution the enzyme belongs to the ornithine cyclodeaminase/l-crystallin (OCD/CRYM) superfamily -, 742532
Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.B5metabolism the enzyme is involved in the trans-3-hydroxy-L-proline metabolism -, 729750
Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.B5metabolism the enzyme performs the second step of the trans-3-hydroxy-L-proline (T3LHyp) degradation pathway -, 763843
Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.B5physiological function approximately 40% of L-proline in collagen are post-translationally converted by proline hydroxylases into the isomers trans-4-hydroxy-L-proline (T4LHyp) and trans-3-hydroxy-L-proline (T3LHyp). The isomers trans-3-hydroxy-L-proline (T3LHyp) and trans-4-hydroxy-L-proline (T4LHyp) are major components of mammalian collagen. T4LHyp follows two distinct degradation pathways in bacteria and mammals, while T3LHyp is metabolized by a two-step metabolic pathway that is conserved in bacteria and mammals, which involves a T3LHyp dehydratase and a DELTA1-pyrroline-2-carboxylate (Pyr2C) reductase -, 763843
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