EC Number   |
General Information |
Reference |
|---|
   1.4.4.2 | malfunction |
glycine decarboxylase (GLDC) knockdown disrupts purine and central carbon metabolism and reduces citrate production, leading to a decrease in the steady-state levels of cholesterol and fatty acids |
765486 |
| 1.4.4.2 | malfunction |
glycine encephalopathy (GCE) or nonketotic hyperglycinemia is an inborn error of glycine metabolism, inherited in an autosomal recessive manner due to a defect in any one of the four enzymes aminomethyltransferase (AMT), glycine decarboxylase (GLDC), glycine cleavage system protein-H (GCSH) and dehydrolipoamide dehydrogenase in the glycine cleavage system. This defect leads to glycine accumulation in body tissues, including the brain, and causes various neurological symptoms such as encephalopathy, hypotonia, apnea, intractable seizures and possible death. Mutations in both GLDC and AMT genes are the main cause of GCE in Malaysian population |
743023 |
| 1.4.4.2 | malfunction |
non-ketotic hyperglycinemia is an autosomal recessive inborn error of metabolism and is caused by a glycine cleavage system deficiency, resulting in high levels of glycine in all tissues including the brain |
765473 |
| 1.4.4.2 | metabolism |
glycine decarboxylase is a key enzyme of glycine cleavage system that converts glycine into one-carbon units |
765452 |
| 1.4.4.2 | metabolism |
glycine decarboxylase is a major enzyme that is involved in the C1 metabolism of all organisms and in the photorespiratory pathway of plants and cyanobacteria. GCS is also essential in the plant photorespiratory C2 cycle, which salvages 2-phosphoglycolate resulting from the oxygenation reaction catalysed by ribulose-1,5-bisphosphate carboxylase/oxygenase under atmospheric conditions. The complete GCS reaction cycle requires the cooperation of three different enzymes, P-protein, T-protein and L-protein, and the small heat-stable H-protein, pathway overview |
710748 |
| 1.4.4.2 | metabolism |
the glycine decarboxylase complex, GDC, is a key enzyme of the photorespiratory C2 cycle in C3 plants, regulation of plant glycine decarboxylase by S-nitrosylation and glutathionylation, overview. GDC activity is inhibited by S-nitrosoglutathione due to S-nitrosylation/S-glutathionylation of several cysteine residues |
713311 |
| 1.4.4.2 | more |
glycine decarboxylase, or P-protein, is part of the glycine cleavage system, GCS |
710748 |
| 1.4.4.2 | more |
the mitochondrial photorespiratory system is involved in the regulation of NO signal transduction in Arabidopsis thaliana |
713311 |
| 1.4.4.2 | physiological function |
critical enzyme of tumor-initiating cells and a driver of tumorigenesis in lung non-small cell cancer |
765869 |
| 1.4.4.2 | physiological function |
enzyme overexpression promotes glycolysis, serine/glycine metabolism, and the accumulation of pyrimidine nucleotides. Enzyme overexpression alone is able to transform NIH 3T3 cells in vitro and drive tumor formation in vivo |
724693 |
