EC Number   |
General Information |
Reference |
|---|
   1.3.99.5 | evolution |
steroid-5alpha-reductases, SRD5alpha, and steroid-5beta-reductase, SRD5beta, represent a convergence in evolution. Phylogenetic analysis of SRD5alpha reveals that SRD5alpha subfamilies include, not only the well-known SRD5alpha type 1, type 2 and type 3, but also the synaptic glycoprotein (GPSN2)/trans-2,3-enoly-CoA reductase group, overview. An eukaryotic ancestor likely underwent duplication events to generate these three subfamilies (type 1/2, type 3 and GPSN2 ancestors), both SRD5alpha type 1/2 and GPSN2 subfamilies may have evolved by ancient duplication events at the early stage of vertebrate and chordate evolution |
712095 |
| 1.3.99.5 | metabolism |
in vertebrates, SRD5alpha and SRD5beta are involved in C-19 and C-21 steroid biosynthesis, bile acid biosynthesis and erythropoiesis |
712095 |
| 1.3.99.5 | more |
comparison of evolution, tissue distribution, enzyme characteristics and biological functions of SRD5alpha and SRD5beta, overview |
712095 |
| 1.3.99.5 | more |
prostate cancer development is accompanied by a decrease in 5alphaR2 and an increase in 5alphaR1 |
713447 |
| 1.3.99.5 | more |
sterol regulatory element binding proteins, SREBPs, regulate expression of Srd5a2 |
711937 |
| 1.3.99.5 | physiological function |
a third type of 5alpha-reductase enzyme type III occurs in hormone-refractory prostate cancer cells |
713519 |
| 1.3.99.5 | physiological function |
conversion of testosterone to 5alpha-dihydrotestosterone by the enzymes 5alpha-reductase types 1, 5alphaR1, and 2, 5alphaR2, is important for normal and pathological growth of the prostate |
713447 |
| 1.3.99.5 | physiological function |
conversion of testosterone to 5alpha-dihydrotestosterone by the enzymes 5alpha-reductase types 1, 5alphaR1, and 2, 5alphaR2, is important for normal and pathological growth of the prostate. Upregulation of 5alphaR1 enhances the cellular response to low, but not high, concentrations of testosterone. This explains one mechanism by which castration-recurrent prostate cancer can proliferate in the presence of castrate levels of circulating testosterone |
713447 |
| 1.3.99.5 | physiological function |
human SRD5alpha deficiencies can lead to pseudohermaphroditism, prostate cancer, polycystic ovarian syndrome and hirsutism. SRD5alpha-deficient patients exhibiting male pseudohermaphrodite phenotype lack the SRD5alpha2 isoform, but exhibited SRD5alpha1 activity |
712095 |
| 1.3.99.5 | physiological function |
inhibition of 5alpha-reductase by dutasteride following castration during human LNCaP tumor regrowth in mice enhances the expression of U19/Eaf2, an androgen-regulated tumor suppressor, real-time RT-PCR expression analysis of genes in response to 5alpha-reductase inhibition, detailed overview |
713449 |
