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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 1.3.98.7physiological function a MftC deletion mutant is unable to grow in minimal medium containing cholesterol (0.01% [wt/vol]) as the sole carbon source with hot ethanol (1% [vol/vol]) as the solvent (cholesterol and EtOH [cholesterol:EtOH]). There is no significant growth retardation in cholesterol:DMSO. Supplementation of ethanol has no effect on mutant strain growth in propionate (0.5% [wt/vol]) or glycerol (0.2% [vol/vol]) but severely delays mutant strain growth in acetate (0.5% [wt/vol]) in comparison with the growth of the wild-type strain. MftC deletion results in multifold increases in expression of the DosR regulon genes in ethanol-treated strains -, 759706
Display the reaction diagram Show all sequences 1.3.98.7physiological function MtfC is a radical SAM enzyme and oxidatively decarboxylates the C-terminus of the MftA peptide in the presence of the accessory protein MftB. MftC abstracts a hydrogen atom from the beta-carbon of the C-terminal Tyr residue. The resulting radical species is stabilized by the adjacent phenol ring. Decarboxylation occurs either via transfer of the unpaired spin from the radical intermediate to a [4Fe-4S] cluster concomitant with decarboxylation to form the final product. Alternatively, the Calpha-COOH bond can be homolytically cleaved resulting in the formation of a COOH radical species that can either be quenched to formate or CO2 -, 760576
Display the reaction diagram Show all sequences 1.3.98.7physiological function radical SAM protein Rv0693 is involved in biosynthesis of cofactor mycofactocin and targets a small peptide for modification -, 760787
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