EC Number   |
General Information |
Reference |
|---|
    1.3.1.84 | evolution |
the enzyme belongs to the the MDR012 family of the medium-chain dehydrogenase/reductase (MDR) superfamily |
745213 |
| 1.3.1.84 | malfunction |
a SPO1914 mutant is unable to grow on acrylate as the sole carbon source, supporting its role in the dimethylsulphoniopropionate assimilation pathway |
745800 |
| 1.3.1.84 | malfunction |
the introduction of codon-optimized SPO_1914 or yhdH into a DELTAacuI::kan mutant of Rhodobacter sphaeroides on a plasmid complements 3-hydroxypropionate-dependent growth. But in their native hosts, SPO_1914 and yhdH are believed to function in the metabolism of substrates other than 3-hydroxypropionate, where acrylyl-CoA is an intermediate. Complementation of the DELTAacuI::kan mutant phenotype by crotonyl-CoA carboxylase/reductase from Rhodobacter sphaeroides is attributed to the fact that the fact that the enzyme also uses acrylyl-CoA as a substrate |
745213 |
| 1.3.1.84 | metabolism |
enzyme SPO_1914 is believed to function in the metabolism of substrates other than 3-hydroxypropionate, where acrylyl-CoA is an intermediate |
745213 |
| 1.3.1.84 | metabolism |
enzyme yhdH is believed to function in the metabolism of substrates other than 3-hydroxypropionate, where acrylyl-CoA is an intermediate |
745213 |
| 1.3.1.84 | metabolism |
Ruegeria pomeroyi DSS-3 possesses two general pathways for metabolism of dimethylsulphoniopropionate (DMSP), an osmolyte of algae and abundant carbon source for marine bacteria. In the DMSP cleavage pathway, acrylate is transformed into acryloyl-CoA by propionate-CoA ligase (SPO2934) and other unidentified acyl-CoA ligases. Acryloyl-CoA is then reduced to propionyl-CoA by AcuI or SPO1914. Acryloyl-CoA is also rapidly hydrated to 3-hydroxypropionyl-CoA by acryloyl-CoA hydratase (SPO0147) |
745800 |
| 1.3.1.84 | metabolism |
the enzyme is part of the 3-hydroxypropionate/4-hydroxybutyrate (3HP/4HB) cycle fixes CO2 in extremely thermoacidophilic archaea, pathway regulation and modeling, enzyme kinetics-based models, reaction kinetics model of the 3HP/4HB cycle, detailed overview |
-, 745689 |
| 1.3.1.84 | metabolism |
the enzyme is part of the 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation cycle, pahway overview |
-, 745491 |
| 1.3.1.84 | metabolism |
the enzyme is part of the proposed reductive pathway for 3-hydroxypropionate assimilation by Rhodobacter sphaeroides 2.4.1, overview |
745213 |
| 1.3.1.84 | more |
two-hybrid assay analysis of the protein interaction of ACR and SSR in Saccharomyces cerevisiae |
-, 745689 |
