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Results 1 - 5 of 5
EC Number General Information Commentary Reference
Show all pathways known for 1.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.2metabolism efficacy of the chemotherapeutic drug 5'-fluorouracil is reduced by catabolism to 2'-fluoro-beta-alanine, a three-step reaction in which dihydropyrimidine dehydrogenase catalyzes the ratelimiting step 712566
Show all pathways known for 1.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.2metabolism in mammals, the pyrimidines uracil and thymine are metabolised by a three-step reductive degradation pathway. Dihydropyrimidine dehydrogenase catalyses its first and rate-limiting step, reducing uracil and thymine to the corresponding 5,6-dihydropyrimidines in an NADPH-dependent reaction 711309
Show all pathways known for 1.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.2metabolism the rate of turnover is not controlled by the protonation state of the general acid, cysteine 671. The initial phase results in the accumulation of charge transfer absorption added to the binding difference spectrum for NADPH. The second phase results in reduction of one of the two flavins. The presumed activated form of the enzyme has the FMN cofactor reduced. Charge transfer arises from the proximity of the NADPH and FAD bases and the ensuing flavin is a result of rapid transfer of electrons to the FMN without accumulation of reduced forms of the FAD or Fe4-S4 centers. The slow rate of turnover of DPD is governed by the movement of a mobile structural feature that carries the C671 residue 762737
Show all pathways known for 1.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.2metabolism the reductive activation of DPD results in the reduction of one flavin per dimer consistent with alternating site behavior. During pyrimidine reduction, electron transfer across the flavins and Fe4S4 centers is rapid relative to the other process. The net rate of transmission of electrons from NADPH to the pyrimidine (kcat) must be determined exclusively by the rate of proton transfer from general acid cysteine 671 762734
Show all pathways known for 1.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.2more the N-terminal half of DPD is a member of a family of FAD-containing NADPH oxidoreductases, which transfer electrons to an acceptor protein or domain through [4Fe-4S] clusters of low to very low potential 711309
Results 1 - 5 of 5