EC Number   |
General Information |
Reference |
|---|
   1.3.1.118 | malfunction |
thermal inactivation of InhA at 42°C in Mycobacterium smegmatis results in the inhibition of mycolic acid biosynthesis, a decrease in hexadecanoic acid (C16:0) and a concomitant increase of tetracosanoic acid (C24:0) in a manner equivalent to that seen in isoniazid-treated cells. The InhA-inactivated cells, like isoniazid-treated cells, undergo a drastic morphological change, leading to cell lysis. InhA inactivation, alone, is sufficient to induce the accumulation of saturated fatty acids, cell wall alterations, and cell lysis |
-, 748073 |
| 1.3.1.118 | metabolism |
InhA belongs to the FAS-II system and participates in the mycolic acid pathway. The long-chain fatty acids produced by the FAS-II system serve as precursors for the formation of the meromycolic acids, which represent the C40-C60 main chain of mycolic acids |
-, 748605 |
| 1.3.1.118 | metabolism |
key enzyme in the biosynthesis of mycolic acids |
-, 747498 |
| 1.3.1.118 | metabolism |
key enzyme involved in the biosynthesis of long-chain fatty acids and of mycolic acids, specific components of the mycobacterial cell wall |
746762 |
| 1.3.1.118 | metabolism |
the enzyjme is a member of an FAS-II system that prefers longer chain fatty acylsubstrates for the purpose of synthesizing mycolic acids, a major component of mycobacterial cell walls |
-, 748146 |
| 1.3.1.118 | metabolism |
the enzyme catalyzes the NADH-dependent reduction of long-chain trans-2-enoyl-ACP fatty acids, an intermediate in mycolic acid biosynthesis |
-, 747286 |
| 1.3.1.118 | metabolism |
the enzyme is a member of the mycobacterial type II dissociated fatty acid biosynthesis system |
-, 747703 |
| 1.3.1.118 | metabolism |
the enzyme is an essential enzyme of the mycolic acid biosynthetic pathway |
-, 748680 |
| 1.3.1.118 | metabolism |
the enzyme is involved in mycolic acid biosynthesis |
-, 747053 |
| 1.3.1.118 | metabolism |
the enzyme is involved in mycolic acid biosynthesis. It is part of the dissociative type 2 fatty acid synthase (FASII) system |
748516 |
