EC Number   |
General Information |
Reference |
|---|
   1.21.99.4 | malfunction |
after injury regeneration markedly delays in muscles of mice null for the gene encoding type 2 deiodinase, despite normal circulating 3,5,3'-triiodo-L-thyronine concentrations, Dio2-deficient mice show muscle-specific hypothyroidism |
715736 |
| 1.21.99.4 | malfunction |
bones from adult type 2 iodothyronine deiodinase-knockout mice have reduced toughness and are brittle, displaying an increased susceptibility to fracture. This phenotype is characterized by a 50% reduction in bone formation and a generalized increase in skeletal mineralization |
716774 |
| 1.21.99.4 | malfunction |
enzyme loss contributes to renal carcinogenesis |
745770 |
| 1.21.99.4 | malfunction |
enzyme loss enhances proliferation and migration of renal cancer cells |
746231 |
| 1.21.99.4 | physiological function |
brain D2 is implicated in adaptative responses to infectious stress |
715743 |
| 1.21.99.4 | physiological function |
convert prohormone T4 to biologicalliy active T3 |
697638 |
| 1.21.99.4 | physiological function |
Dio2 up-regulation is involved in cardiac remodelling in dilated cardiomyopathy through activating the thyroid hormone-signalling pathways involving Akt and p38 MAPK |
714664 |
| 1.21.99.4 | physiological function |
enzyme knock-out mice exhibit greater susceptibility to ventilator-induced lung injury than wild-type mice, as evidenced by poorer alveoli integrity and quantified by lung chemokine and cytokine mRNA induction |
728674 |
| 1.21.99.4 | physiological function |
enzyme overexpression inhibits migration of renal cancer cells. Induction of DIO1 expression in KIJ265T cells leads to significantly decreased cellular proliferation and affects the expression of cell cycle genes, inhibiting the expression of genes that stimulate G1-to-S transition (e.g. cyclin E1) while stimulating the expression of cell cycle repressor E2F |
745770 |
| 1.21.99.4 | physiological function |
in red oxidative soleus muscle, isoform Dio2 activity increases 2.3fold after 3 days at 4°C together with the brown adipose tissue Dio2 activity, which increases 10fold. Soleus muscle and the brown adipose tissue Dio2 activities return to the control levels after 10 days of cold exposure, when an increase of 2.8fold in Dio2 activity is detected in white glycolytic gastrocnemius but not in red oxidative gastrocnemius fibers. Propranolol does not prevent muscle Dio2 induction, but it impairs the decrease of Dio2 in the brown adipose tissue and soleus after 10 days at 4°C. Serum total and free T3 is increased during cold exposure in rats |
733061 |
