   1.21.98.2 | metabolism |
the enzyme is involved in the pathway for the biosynthesis of rebeccamycin, i.e. 1,11-dichloro-12-(4-O-methyl-beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, overview. H2O2 produced from the RebO reaction with Trp to form indole-3-pyruvic acid imine can be used to form Cpd I (state of a hemoprotein that is 2 equivalents of oxidation greater than the ferric form and contains an oxoferryl center (FeIV=O) plus a porphyrin p-cation radical) on RebD, and the Cpd I then via radical chemistry forms the C-C bond that links the tryptophan moieties in chromopyrrolic acid |
735561 |
