EC Number   |
General Information |
Reference |
|---|
    1.2.1.70 | metabolism |
enzyme abundance as a critical regulator of Staphylococcus aureus heme synthesis. HemX controls enzyme abundance in heme-proficient cells to regulate heme synthesis |
-, 763419 |
| 1.2.1.70 | metabolism |
glutamyl-tRNA reductase (GluTR) is the key enzyme for heme biosynthesis. The flow of glutamyl-tRNA is diverted from heme biosynthesis towards protein synthesis under oxidative stress conditions. In the C5 pathway, 5-aminolevulinic acid is synthesized from Glu-tRNAGlu in two steps. First, the glutamate moiety of Glu-tRNAGlu is reduced to glutamate semialdehyde (GSA) by glutamyl-tRNA reductase (GluTR), and then GSA is converted to 5-aminolevulinic acid by the glutamate semialdehyde 1-2 aminomutase (GSAM) |
742701 |
| 1.2.1.70 | metabolism |
GluTR is proposed to be the key regulatory enzyme of tetrapyrrole biosynthetic pathway that is tightly controlled at transcriptional and posttranslational levels |
726162 |
| 1.2.1.70 | metabolism |
GluTR is the first committed enzyme of plant 5-aminolevulinic acid synthesis and 5-aminolevulinic acid synthesis has been shown to be the rate limiting step of tetrapyrrole biosynthesis |
725790 |
| 1.2.1.70 | metabolism |
GluTR is the first enzyme committed to tetrapyrrole biosynthesis by the C5-pathway |
724174 |
| 1.2.1.70 | metabolism |
plants synthesize delta-aminolevulenic acid (ALA), the precursor for all tetrapyrrole molecules, from glutamate via a three-step pathway1 The first step is ligation of glutamate to tRNAGlu catalyzed by glutamyl-tRNA synthetase. Then glutamyl-tRNA reductase (GluTR) reduces the tRNAGlu-bound glutamate to glutamate-1-semialdehyde (GSA) in an NADPH-dependent manner. GSA is subsequently isomerized to ALA by a vitamin B6-dependent enzyme, glutamate-1-semialdehyde aminomutase (GSAM). 5-Aminolevulinic acid synthesis is the key regulatory point for the entire tetrapyrrole biosynthetic pathway, and particularly GluTR is subjected to a tight control at the post-translational level |
743807 |
| 1.2.1.70 | metabolism |
the enzyme catalyzes the rate-limiting step of 5-aminolevulinic acid synthesis |
763567 |
| 1.2.1.70 | metabolism |
the enzyme is essential for chlorophyll biosynthesis in rice |
763344 |
| 1.2.1.70 | metabolism |
the enzyme is the first committed enzyme in tetrapyrrole biosynthesis reducing the activated tRNA-bound glutamate to glutamate-1-semialdehyde, which is subsequently transaminated by glutamate-1-semialdehyde aminotransferase (GSAT) to form 5-aminolevulinic acid. 5-Aminolevulinic acid formation is the rate limiting step of tetrapyrrole biosynthesis and temporally controlled by GluTR expression |
743544 |
| 1.2.1.70 | metabolism |
the enzyme is the first unique enzyme in the tetrapyrrole biosynhetic pathway in plants |
741545 |
