EC Number   |
General Information |
Reference |
|---|
    1.2.1.27 | evolution |
evolutionary lineage history of Msdh across kingdoms, MSDH belongs to the aldehyde dehydrogenase (ALDH) superfamily of genes which are highly conserved and widely distributed in almost all organisms across kingdoms. In vivo expression pattern of Magnaporthe oryzae specific ALDH genes during host-pathogen interaction, overview |
-, 762976 |
| 1.2.1.27 | evolution |
the enzyme is a member of the aldehyde dehydrogenase superfamily |
-, 743075 |
| 1.2.1.27 | malfunction |
MoMSDH deletion adversely affected the development of conidiophore and, as a result, conidiophore population as well as the number of conidia per conidiophore produced by the DELTAMomsdh deletion mutants are significantly reduced |
-, 762976 |
| 1.2.1.27 | malfunction |
MSDH malfunction can be a reason for 3-hydroxyisobutyric aciduria, which is a disorder of valine metabolism |
725642 |
| 1.2.1.27 | metabolism |
contribution of the numerous ALDH genes to the fungal pathogenesis, 16 ALDH genes in Magnaporthe oryzae are idetified involved in infection and pathogenesis |
-, 762976 |
| 1.2.1.27 | metabolism |
for MSDH, a major function in the degradation of branched chain amino acids is proposed which is supported by the high sequence homology with characterized MSDHs from bacteria |
-, 722211 |
| 1.2.1.27 | metabolism |
MSDH enzyme is part of the catabolism pathway of L-valine |
725642 |
| 1.2.1.27 | more |
identification of key residues important for substrate recognition and tetrahedral intermediate stabilization. Two basic residues (Arg103 and Arg279) and six hydrophobic residues (Phe150, Met153, Val154, Trp157, Met281, and Phe449) are important for tetrahedral intermediate binding. The backbone amide of Cys280 and the side chain amine of Asn149 function as the oxyanion hole during the enzymatic reaction |
-, 743075 |
| 1.2.1.27 | physiological function |
enzyme MoMsdh exerts minimal influence on the development of vegetative hyphae, but is involved in the regulation of conidiogenesis and conidiophoregenesis in Magnaporthe oryzae. Conidiation constitutes a pivotal developmental stage in fungal life-cycle and represents one of the most durable organs that promote fungal survival and facilitate their efficient dissemination. MoMsdh is involved in the regulating conditions necessary for promoting asexual reproductive development in Magnaporthe oryzae. MoMsdh is essential for pathogenicity of the organism. MoMsdh crucially regulates intracellular level of small branched-chain amino acids and appressoria mediating signalling molecules. MoMsdh specifically controls the localization of Spitzenkoerper in the conidium to ensure polarized speciation of germ tube. MoMsdh enhances membrane integrity by detoxifying alcohol and pyridoxine derived reactive osmolytes |
-, 762976 |
| 1.2.1.27 | physiological function |
the enzyme is involved in the decarboxylation of methylmalonate-semialdehyde (MMSA) downstream of the dimethylsulfoniopropionate (DMSP) cleavage pathway |
-, 743075 |
