EC Number   |
General Information |
Reference |
|---|
  1.14.99.46 | metabolism |
RutA has a central role in the Rut pathway, a pyrimidine catabolic pathway, which is composed of seven proteins, all of which are required by Escherichia coli K-12 to grow on uracil as the sole nitrogen source, pathway overview. RutA works in conjunction with the flavin reductase RutF |
717729 |
| 1.14.99.46 | metabolism |
RutA is involved in the pyrimidine catabolic Rut pathway, which converts uracil to 3-hydroxypropionate or 2-methyl-3-hydroxypropionate. The flavoenzyme RutA, along with the flavin reductase RutF, catalyzes the initial uracil ring opening by an unprecedented oxidative hydrolysis reaction to give 3-ureidoacrylate |
717703 |
| 1.14.99.46 | metabolism |
RutA is the first enzyme of the pyrimidine catabolizing Rut pathway, the involved enzymes are encoded by the rut operon, including rutRABCDEFG and ydfG, overview. RutF functions as a flavin reductase that is required to regenerate the flavin mononucleotide, FMN, cofactor |
717728 |
| 1.14.99.46 | more |
the Rut pathway degrades exogenous pyrimidines as the sole nitrogen source at room temperature but not at 37°C, a restriction that is apparently a consequence of an inadequate ability to remove toxic malonic semialdehyde at the higher temperature, RutE/YdfG function. The catabolic pathway is highly expressed even in the absence of exogenous substrate and at 37°C |
717728 |
| 1.14.99.46 | physiological function |
RutA has a central role in the Rut pathway, which is composed of seven proteins, all of which are required by Escherichia coli K-12 to grow on uracil as the sole nitrogen source |
717729 |
