EC Number   |
General Information |
Reference |
|---|
   1.14.99.24 | metabolism |
3-ketosteroid 9alpha-hydroxylase is a critical pathogenicity factor of strainH37Rv involved in steroid and cholesterol catabolism |
-, 716250 |
| 1.14.99.24 | metabolism |
key enzyme in steroid degradation. The two key enzymes, 3-ketosteroid DELTA1-dehydrogenase, KsdD, and 3-ketosteroid 9alpha-hydroxylase, KSH, are essential for the production and accumulation of 4-androstene-3,17-dione and 1,4-androstadiene-3,17-dione from soy bean, Glycine max |
-, 713784 |
| 1.14.99.24 | more |
DELTAkshA and DELTAkshB deletion mutants of strain H37Rv are unable to use cholesterol and 4-androstene-3,17-dione as primary carbon and energy sources, and are also unable to metabolize the steroid substrate 5alpha-androstane-3,17-dione in contrast to the wild-type enzyme. The deletion of either of these genes leads to rapid death of the microorganism in murine infection models and in macrophages, showing that kshA and kshB are essential factors for Mycobacterium tuberculosis pathogenesis |
-, 716250 |
| 1.14.99.24 | physiological function |
genes kshA and kshB are essential factors for Mycobacterium tuberculosis pathogenesis |
-, 716250 |
