1.14.20.9 | physiological function |
in the biosynthetis of paerucumarin, PvcA generates an isonitrile-functionalized tyrosine, (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate, that is oxidized by PvcB to give the unsaturated intermediate compound (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate. Oxidation of this compound to a catechol by PvcC/D, followed by intermolecular cyclization of the catechol and the carboxylate, gives paerucumarin. Pseudomonas aeruginosa strains produced a different ratio of paerucumarin to pseudoverdine. PAO1 produces almost exclusively paerucumarin, while PA14 produces approximately a one-to-one mixture of paerucumarin and pseudoverdine |
745208 |