EC Number   |
General Information |
Reference |
|---|
   1.14.19.58 | evolution |
structure comparisons reveal subtle amino acid differences within the MibH substrate binding site generates a solvent exposed crevice presumably involved in determining the substrate specificity of this unusual peptide halogenase |
-, 743917 |
| 1.14.19.58 | malfunction |
a gene disruption mutant in the tryptophan 5-halogenase gene no longer produces the pyrroindomycin B, but still produces pyrroindomycin A, the nonhalogenated derivative |
-, 673021 |
| 1.14.19.58 | physiological function |
expression in Arabidopsis thaliana leads to the formation of 5-chlorotryptophan, 5-chloroindole-3-acetonitrile and 5-chloro-3-indole acetic acid |
744720 |
| 1.14.19.58 | physiological function |
MibH is an FADH2-dependent Trp halogenase, that is only active when Trp is embedded within its cognate peptide substrate deschloro NAI-107 |
-, 743917 |
| 1.14.19.58 | physiological function |
the enzyme is involved in the biosynthesis of the antibiotic pyrroindomycin B that contains an indole ring chlorinated in the 5 position |
-, 673021 |
