EC Number   |
General Information |
Reference |
|---|
    1.14.14.23 | evolution |
the enzyme belongs to the cytochrome P450 family |
736800 |
| 1.14.14.23 | malfunction |
heat shock factor-1 ablation not only eliminates heat shock response, but it also transcriptionally upregulates CYP7A1 and MDR1/P-gp axis in atherogenic western diet-diet fed HSF-1 and low density lipoproteins receptor double knock out mice to reduce atherosclerosis |
735897 |
| 1.14.14.23 | metabolism |
bile acids such as chenodeoxycholic acid (CDCA) activate farnesoid X receptor FXR to increase transcription of small heterodimer partner SHP, an atypical nuclear receptor that lacks a DNA binding domain and represses CYP7A1 activation by suppression of transcription factors, liver receptor homolog-1 (NR5A2) and hepatocyte nuclear factor 4a (NR2A1), which are essential for CYP7A1 expression. A second negative feedback mechanism on CYP7A1 is found in the intestine, where activation of FXR induces fibroblast growth factor 15/19, a hormonal signaling molecule that represses CYP7A1 through interaction with the liver fibroblast growth factor receptor 4 via the c-Jun signaling pathway. Role for the vitamin D receptor on CYP7A1 regulation, overview |
-, 736169 |
| 1.14.14.23 | metabolism |
cholesterol 7alpha-hydroxylase, Cyp7a1, catalyzes the rate-limiting step of the classical pathway of bile acid synthesis and is the major mechanism for cholesterol catabolism and removal from the body. Cyp7a1 regulation, detailed overview |
712117 |
| 1.14.14.23 | metabolism |
Cyp7a1 is a bile acid-synthetic enzyme suppressed by FXR signaling in both liver and intestine in mice, bile acid profiling in untreated and bile acid-treated liver and intestine, overview |
-, 736606 |
| 1.14.14.23 | metabolism |
CYP7A1 is an enzyme involved in bile acid synthesis |
711777 |
| 1.14.14.23 | metabolism |
hepatic conversion to bile acids is a major elimination route for cholesterol in mammals. CYP7A1 catalyzes the first and rate-limiting step in classic bile acid biosynthesis, converting cholesterol to 7alpha-hydroxycholesterol. Hydroxylation of the ring system of cholesterol in a regio- and stereospecific manner with further oxidation and shortening of the side chain produces water-soluble bile acids with powerful detergent properties to emulsify dietary lipids. Bile acids also serve as signaling molecules that bind to G-protein-coupled receptors and nuclear hormone receptors that regulate lipid, glucose, and energy metabolism |
736605 |
| 1.14.14.23 | metabolism |
HSF-1 deletion reduces atherosclerosis and enhances dietary cholesterol metabolism, by not only inducing hepatic MDR1/Pgp but also by enhancing CYP7A1 gene expression in the liver. HSF-1 is a metabolic regulator of dietary cholesterol |
735897 |
| 1.14.14.23 | metabolism |
the phosphorylation status of CYP7A1 chromatin is important in CYP7A1 regulation, overview |
712678 |
| 1.14.14.23 | more |
activation of the vitamin D receptor represses hepatic SHP to increase levels of human CYP7A1 and reduce cholesterol |
736169 |
