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Results 1 - 5 of 5
EC Number General Information Commentary Reference
Show all pathways known for 1.14.13.149Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.149malfunction inhibition of quorum sensing by release of phenylacetic acid leads to attenuated virulence of the Burkholderia cenocepacia paaABCDE mutant. Burkholderia cenocepacia paaA and paaE mutants, in which the paaABCDE gene cluster is interrupted, are defective in PAA degradation and are attenuated for virulence in the nematode host model Caenorhabditis elegans. While the mutants of the PAA-CoA monooxygenase complex re attenuated for pathogenicity, mutants of the ring opening or beta-oxidation steps are not, possibly because some by-products are required for pathogenicity but not produced in DELTApaaABCDE. Phenotypes, overview -, 745801
Show all pathways known for 1.14.13.149Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.149metabolism bifunctional PaaABCE acts as a phenylacetyl-CoA ring-1,2-epoxidase/ring-1,2-epoxyphenylacetyl-CoA deoxygenase -, 718163
Show all pathways known for 1.14.13.149Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.149metabolism the enzyme complex is involved in the phenylacteic acid, PAA, degradation pathway, overview -, 745801
Show all pathways known for 1.14.13.149Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.149physiological function loss of PaaABCDE decreases virulence. Deletion of either ligase PaaK or PaaABCDE leads to higher levels of released phenylacetic acid but no differences in levels of internal accumulation compared to the wild-type level. Removal of PaaABCDE in a LuxIR-like quorum sensing system CepR mutant does not impact its attenuated phenotype 763958
Show all pathways known for 1.14.13.149Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.149physiological function the phenylacetic acid degradation pathway of Burkholderia cenocepacia is active during cystic fibrosis-like conditions and is necessary for full pathogenicity of Burkholderia cenocepacia in nematode and rat infection models. Pathogenicity against Caenorhabditis elegans, increased with exogenous N-octanoyl-L-homoserine lactone -, 745801
Results 1 - 5 of 5