EC Number   |
General Information |
Reference |
|---|
   1.14.13.148 | malfunction |
FMO3 deficiency results in trimethylaminuria or the fish-like odour syndrome |
718454 |
| 1.14.13.148 | malfunction |
mutations of the flavin-containing monooxygenase gene FMO3 cause trimethylaminuria |
717652 |
| 1.14.13.148 | malfunction |
trimethylaminuria (fish-odor syndrome) is associated with defective hepatic N-oxidation of dietary-derived trimethylamine catalyzed by flavin-containing monooxygenase |
717640 |
| 1.14.13.148 | metabolism |
isoform FMO3 in human liver may contribute to the toxicity and/or affect efficacy of ethionamide administration |
706824 |
| 1.14.13.148 | metabolism |
the catalytic mechanism comprises a reductive half-reaction and an oxidative half-reaction. In the reductive half-reaction, FAD is reduced by NADPH. In the oxidative half-reaction, the reduced FAD reacts with O2 to form the C4a-(hydro)peroxyflavin |
764744 |
| 1.14.13.148 | metabolism |
the flavin monooxygenase FMO3 contributes to metabolism of anti-tumour triazoloacridinone, C-1305 (5-dimethylaminopropylamino-8-hydroxytriazoloacridinone), in liver microsomes |
718455 |
| 1.14.13.148 | metabolism |
the flavin monooxygenase FMO3 contributes to metabolism of anti-tumour triazoloacridinone, C-1305 (5-dimethylaminopropylamino-8-hydroxytriazoloacridinone), in liver microsomes and Hep-G2 cells |
718455 |
| 1.14.13.148 | physiological function |
isozyme FMO3 regulates the conversion of N,N,N-trimethylamine into its N-oxide and hence controls the release of volatile N,N,N-trimethylamine from the individual |
718454 |
