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1.14.12.19
physiological function
Hca dioxygenase is involved in the consumption of endogenous cinnamic acid but is not required for 3,5-dihydroxy-4-isopropylstilbene antibiotic production. Disruption of hcaE abolishes the stationary-phase-dependent decrease of extracellular cinnamic acid evidenced in the wild-type strain, hcaE disruption increases stlA expression, thus enhancing cinnamic acid synthesis. Effect of cinnamic acid on plu2201 and plu2202 expression requires HcaR, whereas HcaR is not required for cinnamic acid-induced stlA expression
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