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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 1.14.11.B22metabolism EasH converts a six-membered enamine intermediate, generated by lavoenzyme EasA from chanocalvine-I aldehyde, to a cyclopropyl group-containing intermediate, which is reduced to cycloclavine by the nicotinamide adenine dinucleotide phosphate-dependent imine reductase EasG 764001
Display the reaction diagram Show all sequences 1.14.11.B22physiological function EasH is a 2-oxoglutarate-dependent non-heme iron dioxygenase. EasH is a promiscuous and bimodal dioxygenase that catalyzes both the formation of cyclopropyl ring and the asymmetric hydroxylation ergot alkaloids 764001
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