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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.11.1.29drug target the essential residue of oxido-reductase Mycoredoxin-1 (MtMrx-1) identified in the interaction with mycothiol disulfide reductase (MtMtr) and MtAhpE form a platform for structure-guided drug design against the versatile enzyme machinery of the mycothiol-dependent system inside Mycobacterium tuberculosis 741994
Display the word mapDisplay the reaction diagram Show all sequences 1.11.1.29physiological function Mycobacteria employ a versatile machinery of the mycothiol-dependent system, containing the proteins mycothiol disulfide reductase, the oxido-reductase Mycoredoxin-1 (Mrx-1) and the alkyl-hydroperoxide subunit E (AhpE). The mycothiol-dependent protein ensemble regulates the balance of oxidized-reduced mycothiol, to ensure a reductive intracellular environment for optimal functioning of its proteins even upon exposure to oxidative stress 741994
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