EC Number   |
General Information |
Reference |
|---|
   1.11.1.28 | drug target |
immunization with alkyl hydroperoxide reductase subunit C reduces Fusobacterium nucleatum load in the intestinal tract. AhpC as a potential vaccine candidate against inhabitation or infection of Fusobacterium nucleatum in the intestinal tract, which could provide a practical strategy for the prevention of colorectal cancer associated with Fn infection |
-, 758392 |
| 1.11.1.28 | malfunction |
DELTAahpCD strain is notably more sensitive than its parent strain to hydrogen peroxide (H2O2) but not to organic peroxides (tertbutyl hydroperoxide and cumene hydroperoxide), in the early log phase. The catalase activity of the DELTAahpCD strain is affected at a relatively low level of H2O2 stress. The DELTAahpCD strain induces a reduced number of stem nodules in Sesbania rostrata with lowering of nitrogenase activity |
-, 756742 |
| 1.11.1.28 | malfunction |
DELTAahpD1DELTAahpD2 mutants exhibit significantly decreased resistance to adverse stress conditions and increased accumulation of reactive oxygen species (ROS) |
-, 757346 |
| 1.11.1.28 | malfunction |
DELTAohr strain presents a reduced capacity to grow in the presence of either artificial (cumene hydroperoxide and tert-butyl hydroperoxide) or fatty acid hydroperoxides compared with the wild type |
-, 758233 |
| 1.11.1.28 | physiological function |
AhpC is a critical element of the antioxidant defense system of Mycobacterium tuberculosis |
-, 754057 |
| 1.11.1.28 | physiological function |
AhpCD is required for resistance to low concentrations of H2O2 in the free-living stage and during symbiosis with Sesbania rostrata. AhpCD contributes to H2O2 resistance at the early log phase of Azorhizobium caulinodans growth. ahpCD is required for stem nodulation but not root nodulation in Sesbania rostrata |
-, 756742 |
| 1.11.1.28 | physiological function |
AhpD acts as a backup of thioredoxin to provide reducing power for peroxidase |
-, 757346 |
| 1.11.1.28 | physiological function |
AhpD is a critical element of the antioxidant defense system of Mycobacterium tuberculosis |
-, 754057 |
| 1.11.1.28 | physiological function |
alkyl hydroperoxide reductase subunit C acquires chaperone activity under heat stress. High-molecular-weight oligomer formation and the chaperone-like activity of oxidized AhpC depend on the incubation temperature and the period of incubation |
758424 |
| 1.11.1.28 | physiological function |
Mycobacterium tuberculosis persists in host macrophages, where it faces a nutrient-poor environment and is exposed to oxidative and nitrosative stress. The enzyme defends Mycobacterium tuberculosis against oxidative stress |
-, 753793 |
