EC Number   |
General Information |
Reference |
|---|
   1.11.1.27 | malfunction |
enzyme haplodeficiency attenuates astro- and microglia activation around Abeta plaques promoting Abeta deposition and neuritic degeneration |
765401 |
| 1.11.1.27 | malfunction |
peroxiredoxin 6 down-regulation reduces cell proliferation. Enzyme silencing interferes with apoptotic signaling from CD95 but does not induce apoptosis in HepG2 cells |
763922 |
| 1.11.1.27 | malfunction |
Prdx6 null mice show increased lung or liver injury with exposure to hyperoxia, lipopolysaccharide (LPS), or paraquat. Prdx6 null mice as compared to wild type demonstrate increased age-related oxidative damage to their sperm chromatin |
755892 |
| 1.11.1.27 | malfunction |
the prx3 mutation impairs growth in the medium containing peroxides and reduced virulence in mice |
-, 754106 |
| 1.11.1.27 | malfunction |
the prx3 mutation impairs growth in the medium containing peroxides and reduces virulence in mice |
-, 754106 |
| 1.11.1.27 | more |
regulation of Prdx6 gene regulation, overview. Transcription is activated by binding of the transcription factor Nrf2 to the ARE whereas transcription is inhibited by the binding of Nrf3. Prdx6 expression also is responsive to hormonal regulation |
710899 |
| 1.11.1.27 | physiological function |
cells over-expressing Prdx6 show an increase in survival compared to control when oxidatively challenged with hydroperoxides, paraquat, UVB radiation, or OH generated by Cu2+/ascorbate. Prx6 over-expression through adenoviral-mediated intratracheal delivery of a Prdx6 expression vector or in transgenic mice protected lungs from hyperoxic injury. Prdx6 has an important role in the repair of peroxidized cell membranes, at least in lungs, and that both its PHGPx and PLA2 activities play important roles |
755892 |
| 1.11.1.27 | physiological function |
enzyme upregulation attenuates Abeta pathology |
765401 |
| 1.11.1.27 | physiological function |
function of PRDX6 in osteogenic differentiation, bone regeneration, and bone development. It is proposed that PRDX6 is a critical enzyme for cell fate determination of dental pulp stem cell into osteoblast lineages |
755813 |
| 1.11.1.27 | physiological function |
peroxiredoxins, the family of non-selenium glutathione peroxidases, are important antioxidant enzymes that defend a system from the toxic reactive oxygen species |
755815 |
