EC Number   |
General Information |
Reference |
|---|
    1.1.1.365 | evolution |
AnGaaA is identified as the bona fide GalA reductase in Aspergillus niger. AnGaaA is not related to Gar1 proteins |
763698 |
| 1.1.1.365 | evolution |
the enzyme belongs to the NAD(P)+-binding Rossmann fold oxidoreductase family of proteins |
-, 742938 |
| 1.1.1.365 | malfunction |
deletion of the NADPH-dependent D-galacturonate reductase gene results in strains unable to grow on D-galacturonate |
-, 723997 |
| 1.1.1.365 | metabolism |
after import via the D-galacturonic acid transporter encoded by An14g04280, D-galacturonic acid is catabolized by three key enzymes: D-galacturonic acid reductase, L-galactonate dehydratase, and 2-keto-3-deoxy-galactonate aldolase, in Aspegillus niger. The first step in the D-galacturonic acid metabolism is the enzymatic conversion of D-galacturonic acid to L-galactonic acid by D-galacturonic acid reductase. Overexpression of the Aspergillus niger GatA transporter leads to preferential uptake of D-galacturonic acid over D-xylose of mutant strain JS013 and enanced use of D-galacturonic acid compared to D-xylose. Increased activity of the D-galacturonic acid metabolic pathway is observed for strain JS013 transformant strain in comparison to the control |
-, 741576 |
| 1.1.1.365 | metabolism |
D-galacturonate reductase (GalUR) is a key enzyme involved in D-galacturonate pathway of AsA biosynthesis. L-Ascorbic acid (AsA) biosynthesis through the L-galactose pathway supplemented by D-galacturonic acid pathway and AsA recycling collectively contributes to accumulating and remaining higher AsA level in kiwifruit cv. White during postharvest. L-Galactose dehydrogenase (GalDH) activity and relative expressions of the genes encoding GDP-D-mannose diphosphorylase (GMP), L-galactose-1-P phosphatase (GPP), GDP-L-galactose phosphorylase (GGP), GalDH and GalUR are important for regulation of AsA biosynthesis. The activity and expression of dehydroascorbate reductase (DHAR) are primarily responsible for regulation of AsA recycling in kiwifruit cv. White during postharvest. Changes in activities of enzymes involved in AsA metabolism in the fruit during storage, quantitative real-time PCR expression analysis. A minor change is observed in GalUR activity. The relative expression of GalUR increases sharply to a peak at day 13, and then decreases gradually and continuously |
763588 |
| 1.1.1.365 | metabolism |
D-galacturonate reductase (GalUR) is important in the ascorbic acid biosynthetic pathway |
741553 |
| 1.1.1.365 | metabolism |
D-galacturonic acid reductase is a key enzyme of the ascorbate biosynthesis pathway |
-, 724580 |
| 1.1.1.365 | metabolism |
enzyme D-galacturonic acid reductase, GalUR, is involved in the D-galacturonic acid pathway for ascorbic acid biosynthesis |
741550 |
| 1.1.1.365 | physiological function |
all of transgenic Solanum lycopersicum lines overexpressing the Fragaria ananassa D-galacturonic acid reductase gene are morphologically indistinguishable over different generations from control lines both in vegetative traits, such as leaf size or plant height, and fruit traits such as color or size. The majority of transgenic plants display a slight increase in fruit yield, up to 1.4fold, which is a consequence of an increase in the number of fruits rather than an increase in fruit weight. The plants show no significant changes in soluble solids of transgenic plants, but a reduction in acidity. Transgenic lines show a moderate increase on AsA content, and complex changes in metabolites are found in transgenic fruits. Phenotypes, overview |
742163 |
| 1.1.1.365 | physiological function |
D-galacturonate reductase (GalUR) plays a prominent role in the regulation of the ascorbate biosynthetic pathway. The overexpression of gene GalUR gene enhances the level of ascorbate and Fe(II) of transgenic tomato plants which show better growth than wild-type plants under iron stresses. Ascorbate is a cofactor for many enzymes and affects the expression of genes involved in defense signaling pathways. It plays an important role as an antioxidant and protects the plant during oxidative damage by scavenging free radicals and reactive oxygen species that are generated during photosynthesis, oxidative metabolism and various abiotic stresses including excess light, soil water stress, UV-B radiation, and ozone |
741553 |
