EC Number |
General Information |
Reference |
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1.1.1.36 | metabolism |
AKR1B15.1 is a mitochondrial carbonyl reductase. Two alternatively spliced protein isoforms encoded by the human AKRgene AKR1B15 exist, the AKR1B15.1 isoform catalyzes reduction of steroids and 3-keto-acyl-CoA conjugates |
740743 |
1.1.1.36 | metabolism |
KCR catalyzes the first reduction during elongation of very-long-chain fatty acids, VLCFA, precursors of sphingolipids, triacylglycerols, cuticular waxes, and suberin in plants, but only AtKCR1 is a functional KCR isoform involved in microsomal fatty acid elongation |
700827 |
1.1.1.36 | metabolism |
poly-3-hydroxybutyrate (PHB) is generated from from acetyl CoA by the consecutive reaction of three enzymes: beta-ketothiolase (EC 2.3.1.9), acetoacetyl CoA reductase (EC 1.1.1.36) and PHB synthase (EC 2.3.1.) in corn roots |
740906 |
1.1.1.36 | metabolism |
poly-3-hydroxybutyrate (PHB) is generated from from acetyl CoA by the consecutive reaction of three enzymes: beta-ketothiolase (EC 2.3.1.9), acetoacetyl CoA reductase (EC 1.1.1.36) and PHB synthase (EC 2.3.1.) in rice roots |
740906 |
1.1.1.36 | metabolism |
poly-3-hydroxybutyrate (PHB) is generated from from acetyl CoA by the consecutivereaction of three enzymes: beta-ketothiolase (EC 2.3.1.9), acetoacetyl CoA reductase (EC 1.1.1.36) and PHB synthase (EC 2.3.1.) in rice roots |
740906 |
1.1.1.36 | metabolism |
the enzyme is rate-limiting in poly(3-hydroxybutyrate) biosynthesis. Poly(3-hydroxybutyrate) (P(3HB)) is synthesized from acetyl-CoA via three successive reactions. Two molecules of acetyl-CoA are condensed into acetoacetyl-CoA by a beta-ketothiolase (PhaA). Then NADPH-dependent acetoacetyl-CoA reductase (PhaB) converts acetoacetyl-CoA into (R)-3-hydroxybutyryl-CoA (3HB-CoA), which is finally polymerized into P(3HB) by polyhydroxyalkanoate synthase (PhaC) |
-, 740184 |
1.1.1.36 | more |
PhaB forms a ternary complex with NADPH and acetoacetyl-CoA |
-, 739901 |
1.1.1.36 | physiological function |
suppressed KCR activity results in a reduction of cuticular wax load and affects VLCFA composition of sphingolipids, seed triacylglycerols, and root glycerolipids |
700827 |
1.1.1.36 | physiological function |
the enzyme is dispensable for mycobacterial growth |
-, 760524 |