EC Number   |
General Information |
Reference |
|---|
    1.1.1.184 | evolution |
the enzyme belongs to the aldo-keto reductase (AKR) superfamily of NAD(P)(H)-dependent oxidoreductases |
-, 721912 |
| 1.1.1.184 | evolution |
the enzyme is a member of the aldo-keto-reductase family (AKR) |
-, 722137 |
| 1.1.1.184 | evolution |
the enzyme is a member of the short-chain dehydrogenase/reductase (SDR) family |
-, 721234 |
| 1.1.1.184 | malfunction |
pharmacological inhibition of carbonyl reductase 1 in diet-induced obesity in mice results in more marked glucose intolerance with evidence for enhanced hepatic glucocorticoid receptor signaling |
762424 |
| 1.1.1.184 | metabolism |
carbonyl reductase 1 generating 20beta-dihydrocortisol is a pathway modulating glucocorticoid receptor activation and providing enzymatic protection against excessive GR activation in obesity |
762424 |
| 1.1.1.184 | more |
conserved catalytic tetrad D-Y-K-H (Asp53, Tyr58, Lys84, and His117) and putative cofactor binding sites at Asp53, Ser147, Asn148, Gln169, Glu249, and Asn254 |
-, 721912 |
| 1.1.1.184 | physiological function |
CBR1 is upregulated at the transcript level during cell differentiation. CBR1 expression is increased during skeletal muscle regeneration in tibialis anterior muscle after injury induced by cardiotoxin. Intracellular reactice levels and lipid peroxidation are increased incells transfected with CBR1 siRNA |
740534 |
