EC Number   |
General Information |
Reference |
|---|
   1.1.1.105 | evolution |
RDH1, RDH10 and DHRS9 are microsomal members of the SDR gene family |
721724 |
| 1.1.1.105 | evolution |
RDHs that catalyze the interconversion of retinal and retinol involved in rhodopsin turnover are members of the family of short chain dehydrogenase/reductases |
-, 722769 |
| 1.1.1.105 | malfunction |
deleting the positive charges from the C-terminal end of the leader, and inserting two arginine residues near the N-terminus of the signaling sequence causes 95% inversion from cytoplasmic to luminal: i.e. the mutant L3R/L5R/R16Q/R19Q/R21Q faces the lumen |
721724 |
| 1.1.1.105 | malfunction |
mice lacking both the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands. The upregulation of hair-follicle stem cell genes is consistent with reduced retinoic acid signaling in the skin of the double-knockout mice |
-, 761505 |
| 1.1.1.105 | malfunction |
mice with targeted knockout of the more catalytically active SDR16C6 enzyme have no obvious phenotype, possibly due to functional redundancy, because Sdr16c5 and Sdr16c6 exhibit an overlapping expression pattern during later developmental stages and in adulthood. Mice lacking both epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands |
-, 761505 |
| 1.1.1.105 | malfunction |
outer segments of rods deficient in Rdh8 fail to reduce all-trans-retinal. Following exposure to light, a leak of retinoids from outer to inner segments is detected in rods from both wild-type and knock-out mice. In cells lacking Rdh8 or Rdh12, EC 1.1.1.300, this leak is mainly all-trans-retinal, overview. Retinal reductase activity is lost in RDH12-deficient mutants |
-, 722769 |
| 1.1.1.105 | metabolism |
the enzyme catalyzes the first step in all-trans-retinal biosynthesis, modeling of all-trans-retinal homeostasis, overview |
721724 |
| 1.1.1.105 | metabolism |
two murine epidermal retinol dehydrogenases, short-chain dehydrogenase/reductase family 16C member 5 (SDR16C5 or RDHE2) and SDR16C6 (RDHE2S), contribute to retinoic acid biosynthesis in living cells and are also essential for the oxidation of retinol to retinaldehyde in vivo |
-, 761505 |
| 1.1.1.105 | metabolism |
two murine epidermal retinol dehydrogenases, short-chain dehydrogenase/reductase family 16C member 5 (SDR16C5 or RDHE2) and SDR16C6 (RDHE2S), contribute to retinoic acid biosynthesis in living cells and are also essential for the oxidation of retinol to retinaldehyde in vivo. RDHE2S is a more active enzyme than RDHE2 |
-, 761505 |
| 1.1.1.105 | more |
N-ethylmaleimide does not affect the catalytic action of RDH1, but interferes with its approach to holo-CRBP1, interrupting retinol transfer. The membrane context of RDH affects function |
721724 |
