EC Number   |
General Information |
Reference |
|---|
   1.1.1.103 | evolution |
the enzyme belongs to the extended short-chain alcohol dehydrogenase superfamily |
-, 721272 |
| 1.1.1.103 | malfunction |
knockdown of the enzyme and posttranslational downregulation by microRNA-9 inhibits reprogramming efficiency |
723777 |
| 1.1.1.103 | metabolism |
key enzyme in the metabolism of L-threonine |
762567 |
| 1.1.1.103 | metabolism |
rate-limiting enzyme of threonine degradation |
-, 762608 |
| 1.1.1.103 | more |
active site structure and subunit interaction, overview |
722747 |
| 1.1.1.103 | more |
the enzyme possesses a glycine-rich NAD+-binding domain at the N terminus and conserved catalytic triad of YxxxK residues |
-, 721272 |
| 1.1.1.103 | physiological function |
embryonic stem cells are critically dependent on the amino acid threonine, and threonine catabolism via the TDH enzyme is important to the growth and metabolic state of mouse embryonic stem cells |
710562 |
| 1.1.1.103 | physiological function |
over-expression of a feedback-resistant threonine operon thrA*BC, with deletion of the genes that encode threonine dehydrogenase tdh and threonine transporters tdcC and sstT, and introduction of a mutant threonine exporter rhtA23 in Escherichia coliMDS42. The resulting strain shows about 83% increase in L-threonine production when cells are grown by flask fermentation, compared to a wild-type Escherichia coli strain MG1655 engineered with the same threonine-specific modifications described above |
-, 709827 |
| 1.1.1.103 | physiological function |
the enzyme plays an important role in the regulation of somatic cell reprogramming |
723777 |
