EC Number   |
General Information  |
Reference |
|---|
   5.4.99.B4 | malfunction |
cbf5 deletion reduces the amounts of guide box H/ACA RNAs |
-, 716902 |
| 5.4.99.B4 | malfunction |
deletion of cbf5 does not lead to any obvious phenotype, the Cbf5-deleted strain of Haloferax volcanii completely lacks pseudouridine at positions 1940, 1942, 2605, and 2591 of its 23S rRNA, and contains reduced steady-state levels of some box H/ACA RNAs |
-, 716902 |
| 5.4.99.B4 | malfunction |
inactivation of the RluD pseudouridine synthase has minimal effects on growth and ribosome function |
715376 |
| 5.4.99.B4 | malfunction |
inactivation of the RluD pseudouridine synthase has minimal effects on growth and ribosome function. Deletion of rluD is associated with extremely slow growth, increased readthrough of stop codons, and defects in 50S ribosomal subunit assembly and 30S-50S subunit association |
715376 |
| 5.4.99.B4 | physiological function |
the Cbf5 homolog (HVO 2493) is not essential in Haloferax volcanii. Cbf5 is not needed for most of the tRNA pseudouridine residues of Haloferax volcanii |
-, 716902 |
| 5.4.99.B4 | physiological function |
the enzyme Cbf5 is responsible for making pseudouridine at multiple positions of the large subunit of rRNA |
-, 716902 |
| 5.4.99.B4 | physiological function |
the enzyme usually acts in a guide RNA-dependent manner as part of H/ACA small ribonucleoproteins, however, archaeal Cbf5 can also act independently of guide RNA in modifying uridine 55 in tRNA |
730948 |
