EC Number   |
General Information  |
Reference |
|---|
    4.3.3.6 | malfunction |
a btrC2 disruptant shows deficiency in growth and antibiotic production, and the addition of pyridoxal to the medium restores growth and short-term antibiotics production |
-, 729433 |
| 4.3.3.6 | malfunction |
deletion of the pdxST genes in Corynebacterium glutamicum NJ0898 results in vitamin B6 auxotrophy, which is restored by external pyridoxal, pyridoxal 5'-phosphate or pyridoxamine |
-, 716150 |
| 4.3.3.6 | malfunction |
the disruption of the PdxS gene generates a vitamin B6 auxotrophic Mycobacterium tuberculosis mutant |
-, 729134 |
| 4.3.3.6 | metabolism |
the organism synthesizes pyridoxal 5'-phosphate via the deoxyxylulose 5-phosphate (DXP)-dependent pathway |
-, 729134 |
| 4.3.3.6 | more |
proteins PdxS and PdxT interact physically and form the PLP synthase, PdxT is a glutamine amidotransferase subunit that donates an amido group from glutamine to the intermediate of the enzyme reaction |
729433 |
| 4.3.3.6 | more |
the overall structure of the protein, composed of a (beta/alpha)8-barrel and two small 310-helices, is quite similar to those of other PdxS proteins. Rv2606c and Rv2604c form a stable complex, suggesting that these proteins might function as pyridoxal biosynthesis lyase and glutamine amidotransferase, respectively |
-, 729134 |
| 4.3.3.6 | physiological function |
vitamin B6 biosynthesis is essential for the survival and virulence of Mycobacterium tuberculosis |
-, 729134 |
