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Results 1 - 7 of 7
EC Number
General Information
Commentary
Reference
malfunction
a btrC2 disruptant shows deficiency in growth and antibiotic production, and the addition of pyridoxal to the medium restores growth and short-term antibiotics production
malfunction
deletion of the pdxST genes in Corynebacterium glutamicum NJ0898 results in vitamin B6 auxotrophy, which is restored by external pyridoxal, pyridoxal 5'-phosphate or pyridoxamine
malfunction
the disruption of the PdxS gene generates a vitamin B6 auxotrophic Mycobacterium tuberculosis mutant
metabolism
the organism synthesizes pyridoxal 5'-phosphate via the deoxyxylulose 5-phosphate (DXP)-dependent pathway
more
proteins PdxS and PdxT interact physically and form the PLP synthase, PdxT is a glutamine amidotransferase subunit that donates an amido group from glutamine to the intermediate of the enzyme reaction
more
the overall structure of the protein, composed of a (beta/alpha)8-barrel and two small 310-helices, is quite similar to those of other PdxS proteins. Rv2606c and Rv2604c form a stable complex, suggesting that these proteins might function as pyridoxal biosynthesis lyase and glutamine amidotransferase, respectively
physiological function
vitamin B6 biosynthesis is essential for the survival and virulence of Mycobacterium tuberculosis
Results 1 - 7 of 7