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General Information
physiological function
DCTPP1-deficient cells accumulate high levels of dCTP and are hypersensitive to exposure to the nucleoside analogues 5-iodo-2'-deoxycytidine and 5-methyl-2'-deoxycytidine
physiological function
knockdown of DCTPP1 in breast cancer cell line MCF-7 cells remarkably retards proliferation and colony formation in vitro. The capacity of mammosphere formation of MCF-7 is suppressed with the silence of DCTPP1, consistent with the enhanced mammosphere-forming ability in DCTPP1-overexpressing MDA-MB-231 cells. The global methylation level is elevated in DCTPP1-knockdown MCF-7 cells or mammosphere-forming MCF-7 cells but decreased significantly in DCTPP1-overexpressing MDA-MB-231 cells and its mammosphere
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