EC Number   |
General Information |
Reference |
|---|
   3.4.22.55 | physiological function |
apoptosis induced by doxorubicin and 5-fluorouracil is caspase-2-dependent |
710904 |
| 3.4.22.55 | malfunction |
both pharmacological inhibition and shRNA-mediated knockdown of caspase-2 suppresses myogenic differentiation and dramatically impaired myotube formation |
752842 |
| 3.4.22.55 | physiological function |
Brucella abortus strain RB51- and S2308-induced BMDC cell death is regulated by caspase-2. The enzyme is required for naive T-lymphocyte proliferation following stimulation with RB51-infected bone marrow-derived dendritic cells |
732704 |
| 3.4.22.55 | malfunction |
Casp2-null animals develop normally, and thymocytes and neurons derived from them seem to undergo similar levels of apoptosis to those from wild-type littermates. Nevertheless, several subtle phenotypes are associated with the Casp2-knockout mice: Casp2-knockout females have a slight increase in the number of oocytes and Casp2/ oocytes show reduced apoptosis in response to treatment with doxorubicin. The neurons derived from Casp2-null mice are resistant to beta-amyloid-mediated death, which suggests a role for caspase 2 in neuronal death. Casp2-deficient mice also show signs of premature ageing, including accumulation of oxidative damage. Mouse embryonic fibroblasts from Casp2-deficient animals show a reduced or delayed apoptotic response to some cytotoxic drugs, have an aberrant DNA damage and cell cycle response and are readily transformed when they are challenged by oncogene expression. |
713092 |
| 3.4.22.55 | physiological function |
caspase 2 is thought be a downstream caspase |
713092 |
| 3.4.22.55 | physiological function |
caspase 2 represses transcription of the survivin gene, a general regulator of cell division and cytoprotection in tumors. This pathway involves caspase 2 proteolytic cleavage of the nuclearfactor kappaB (NFkappaB) activator, RIP1. Loss of RIP1 abolishes transcription of NFkappaB target genes, including survivin, resulting in deregulated mitotic transitions, enhanced apoptosis and suppression of tumorigenicityin vivo. Caspase 2 functions as an endogenous inhibitor of NFkappaB-dependent cell survival. |
713154 |
| 3.4.22.55 | physiological function |
caspase-2 activation is commonly associated with induction of IFN-beta-induced apoptosis in IFN-beta-sensitive melanoma cells |
712665 |
| 3.4.22.55 | physiological function |
caspase-2 acts as a tumor suppressor. Loss of caspase-2 leads to an acceleration of tumor onset in the EMy-Myc mouse lymphoma model |
753078 |
| 3.4.22.55 | metabolism |
caspase-2 cleavage of tau at Asp314 impairs cognitive and synaptic function in animal and cellular models of tauopathies by promoting the missorting of tau to dendritic spines. The truncation product, DELTAtau314, resists fibrillation and is present at higher levels in brains from cognitively impaired mice and humans with Alzheimer's disease |
754859 |
| 3.4.22.55 | metabolism |
caspase-2 cleavage of tau at Asp314 impairs cognitive and synaptic function in animal and cellular models of tauopathies by promoting the missorting of tau to dendritic spines. The truncation product, DETAtau314, resists fibrillation and is present at higher levels in brains from cognitively impaired mice and humans with Alzheimer's disease |
754859 |
