EC Number   |
General Information |
Reference  |
|---|
   3.4.22.53 | malfunction |
calpain inhibition blocks the increased colonic epithelial cell invasion caused by NM IIA knockdown |
707044 |
| 3.4.22.53 | physiological function |
mitochondrial m-calpain is associated with ERp75 and plays an important role in releasing of truncated apoptosis-inducing factor from mitochondria |
707281 |
| 3.4.22.53 | physiological function |
calpain-2 is involved in cell motility |
707365 |
| 3.4.22.53 | physiological function |
mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria by cleaving voltage-dependent anion channel |
707559 |
| 3.4.22.53 | malfunction |
in vivo knockdown of calpain2 disrupts metastasis among apoptosis-resistant tumors |
707980 |
| 3.4.22.53 | physiological function |
calpain-2 is crucial for promotion of migration and metastasis by caspase-8 |
707980 |
| 3.4.22.53 | malfunction |
short interfering RNA-induced silencing of m-calpain results in increased RhoA activity and hyperpermeability in the aortic arch, which is accompanied by ROCK inhibitor-sensitive phosphorylation of downstream effecter LIM kinase 2, stress fibre accumulation in endothelium and enhanced interendothelial gaps |
708018 |
| 3.4.22.53 | physiological function |
m-calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions |
708018 |
| 3.4.22.53 | physiological function |
an endoplasmic reticulum stress-related calpain-down-regulated PPAR-gamma/HO-1 pathway is involved in the interleukin-13-enhanced activated death of microglia |
708062 |
| 3.4.22.53 | malfunction |
calpain 2 depletion impairs mitosis and induces apoptosis, low Capn2 levels induce chromosome alignment defects, the loss of histone H3 threonine 3 phosphorylation at centromeres, and premature sister chromatid separation |
708140 |
