EC Number   |
General Information  |
Reference |
|---|
   3.4.22.53 | malfunction |
calpain 2 depletion impairs mitosis and induces apoptosis, low Capn2 levels induce chromosome alignment defects, the loss of histone H3 threonine 3 phosphorylation at centromeres, and premature sister chromatid separation |
708140 |
| 3.4.22.53 | malfunction |
calpain 2 knockdown in breast cancer cells correlates with reduced in vitro proliferation, migration, and in vivo tumorigenicity as well as reduced Akt activation, increased nuclear FoxO localization, and increased p27Kip1 expression |
732050 |
| 3.4.22.53 | malfunction |
calpain inhibition blocks the increased colonic epithelial cell invasion caused by NM IIA knockdown |
707044 |
| 3.4.22.53 | malfunction |
calpain inhibition favors differentiation of neuronal stem cells. Calpain 2 silencing elicits decreased levels of glial fibrillary acidic protein |
732688 |
| 3.4.22.53 | malfunction |
in vivo knockdown of calpain2 disrupts metastasis among apoptosis-resistant tumors |
707980 |
| 3.4.22.53 | malfunction |
inhibition of calpain activity limits cell migration and in vitro wound healing of IEC-6 cells |
717669 |
| 3.4.22.53 | malfunction |
inhibition of m-calpain induces expression of the adult alpha- and beta-globin genes |
709031 |
| 3.4.22.53 | malfunction |
knockdown of calpain 2 expression or chemical inhibition of calpain activity reduces glioblastoma cell invasion by 90%. Decreased expression of calpain 2 does not influence morphology or migration |
718169 |
| 3.4.22.53 | malfunction |
knockdown of calpain 2 inhibits T cell migration at both the level of single cell tracking and general cell speed |
718262 |
| 3.4.22.53 | malfunction |
knockdown of calpain 2 results in a 2.9fold decrease in the invasion of human glioblastoma cells in zebrafish brain. Calpain 2 knockdown cells demonstrate a 2.3fold lower area of dispersal compared with control cells |
732365 |
