EC Number |
General Information |
Reference |
---|
3.4.22.53 | physiological function |
an endoplasmic reticulum stress-related calpain-down-regulated PPAR-gamma/HO-1 pathway is involved in the interleukin-13-enhanced activated death of microglia |
708062 |
3.4.22.53 | physiological function |
Ca2+ overload induces apoptosis, which was correlated with calpain-2 activation |
708389 |
3.4.22.53 | physiological function |
calpain 2 activation is an early event in heat stress-induced male germ cell apoptosis |
709241 |
3.4.22.53 | physiological function |
calpain 2 controls turnover of lymphocyte function-associated antigen-1 adhesions on migrating T lymphocytes |
718262 |
3.4.22.53 | malfunction |
calpain 2 depletion impairs mitosis and induces apoptosis, low Capn2 levels induce chromosome alignment defects, the loss of histone H3 threonine 3 phosphorylation at centromeres, and premature sister chromatid separation |
708140 |
3.4.22.53 | physiological function |
calpain 2 is involved in glial differentiation |
732688 |
3.4.22.53 | physiological function |
calpain 2 is required for matrix metalloproteinase-2 activity in glioblastoma cells. Calpain 2 is required for glioblastoma cell invasion, but not migration |
718169 |
3.4.22.53 | physiological function |
calpain 2 is required for sister chromatid cohesion |
708140 |
3.4.22.53 | physiological function |
calpain 2 is required for the invasion of glioblastoma cells in the living zebrafish brain microenvironment |
732365 |
3.4.22.53 | malfunction |
calpain 2 knockdown in breast cancer cells correlates with reduced in vitro proliferation, migration, and in vivo tumorigenicity as well as reduced Akt activation, increased nuclear FoxO localization, and increased p27Kip1 expression |
732050 |